PROTA LYN REVIEW FULL

Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.

Cross SL, Halden NF, Lenardo MJ, Leonard WJ.

The x gene is essential for HTLV replication.

Chen IS, Slamon DJ, Rosenblatt JD, Shah NP, Quan SG, Wachsman W.

Purification and biochemical characterization of the promoter-specific transcription factor, Sp1.

Briggs MR, Kadonaga JT, Bell SP, Tjian R.

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat.

Brady J, Jeang KT, Duvall J, Khoury G.HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene.

Ballard DW, Böhnlein E, Lowenthal JW, Wano Y, Franza BR, Greene WC.

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PROTA LYN REVIEW FULL

Full textįull text is available as a scanned copy of the original print version. Cotransfection of various chloramphenicol acetyltransferase constructs containing different length of the lyn promoter together with p40tax expression plasmids into Jurkat T cells showed that the sequence responsible for p40tax-induced transcription is present around the transcription initiation sites.

Mutational analysis suggested that the octamer-binding motif sequence is of primary importance for the lyn promoter activity but that the other elements are not. In addition, it contained sequences characteristic of a cyclic AMP-responsive element, octamer-binding motif, PEA3-like motifs, and NF kappa B-binding motif-like sequence. Nucleotide sequence analysis revealed that the lyn promoter region contained four GC box-like sequences but not a TATA or CCAAT box. This fragment showed promoter activity when placed upstream of the bacterial chloramphenicol acetyltransferase gene and transfected into various cell lines. By endonuclease S1 mapping, the transcriptional initiation sites were identified within the 770-bp EcoRI-SacI fragment of the 5'-terminal portion of the human lyn gene. For determination of the mechanism of p40tax-mediated trans activation, the transcriptional promoter region of the lyn gene was characterized. Transcription of the lyn gene in T lymphocytes was shown to be induced by the p40tax protein encoded by human T-cell lymphotropic virus type I. Prota also provides services in project and construction management, design and construction supervision, systems engineering, quality control and contract management.The src family gene lyn is expressed preferentially in B lymphocytes but very little in normal T lymphocytes. Prota also has extensive expertise in earthquake engineering and has pioneered innovative methodologies for upgrading buildings and infrastructure to meet the demands of new safety standards. Specialized in architectural and engineering design of high-rise buildings, public facilities including sports complexes, business centers, healthcare and educational facilities, Large scale transportation structures including railway stations and airports, light and heavy industrial buildings as well as execution of feasibility studies, infrastructure projects, and urban and regional planning. Prota is a one of Turkey’s leading engineering consultancy firms with a track record of delivering innovative project design and specialist services around the world.Prota draws from an experienced team of partners and experts from a range of backgrounds including engineers, architects, planners, project managers and BIM specialists.

Prota lyn review